In-Silico Molecular Docking And Drug-Likeness, Medicinal Chemistry, Toxicity Properties Of Antidiabetic Compounds Present In Citrullus Lanatus

Abstract

The current study uses gas chromatography-mass spectrometry assessment, in-silico molecular docking, drug-likeness, medicinal chemistry, and toxicity screening to identify anti-diabetic compounds in Citrullus lanatus leaves. The extracts were subjected to gas chromatography-mass spectrometry and molecular docking. The gas chromatography-mass spectrometry analysis discovered the existence of seven compounds Citrullus lanatus leaf extracts. Also, from  in - silico analysis, 2r- acetoxy methyl- 1,3,3 -tri methyl- 4t-(3-methyl- 2- buten-1-yl)-1t-cyclo hexanol compound from Citrullus lanatus leaves from Anand city found best antidiabetic potential. Furthermore, all seven compounds drug-likeness, medicinal chemistry and toxicity properties were studied. As a result Citrullus lanatus leaves can be a valuable pharmaceutical agent in the treatment and management of diabetes complications.