Topoisomerase – A Target For Anticancer Agents

Abstract

Topoisomerases are ubiquitous enzymes have significant roles in several critical DNA processes. Over the past few years, there has been considerable interest in DNA topoisomerases, as they were shown to be the cellular targets for several anticancer drugs. The functions of various topoisomerase enzymes related to the maintenance of DNA topology during its replication and transcription are the targets of several anticancer and antimicrobial agents. Targeting topoisomerase enzymes for cancer treatment remains a prominent focus of both fundamental and clinical oriented research. This review aimed to discuss briefly about different anticancer agents target the Topoisomerases