A Pharmacological Mechanistic Appraisal Of Antihyperlipidaemic Activity Of Balbisia Pedunculata Methanol Extract In High Fat Diet Induced Hypelipidemia Model

Abstract

The current study focuses on the ability of Balbisia pedunculata methanolic whole plant extract to decrease cholesterol with hyperlipidemia brought on by a high-fat diet. For six weeks, rats were given an oral high-fat diet to produce hyperlipidemia. After that, the extract was given to hyperlipidaemic rats for the next six weeks at two distinct doses: 250 mg/kg and 500 mg/kg body weight. As a standard, atorvastatin was utilised. The extract demonstrated dose-dependent anti-hyperlipidaemic action. Total cholesterol, LDL-C, VLDL-C, HDL-C, and the atherogenic index were among the evaluation parameters that revealed the dose of 500 mg/kg to have the highest antihyperlipidemic efficacy. These data were comparable to those of the standard medicine, atorvastatin, in each case. These results validate the extract's use in conjunction with current therapies to treat hyperlipidemia.