Design Formulation And Evaluation Of Anti Migraine Mouth Dissolving Tablets Using Different Superdisintegrants

Abstract

Through the application of novel approaches to the administration of medication, the purpose of this study is to enhance the safety, efficacy, and rate of action of the existing molecule. Orally disintegrating pills containing rizatriptan benzoate were manufactured by the direct compression process in order to provide migraine sufferers with a more expedient means of obtaining relief. A 32-factororial design approach was utilized in this investigation, and eight distinct formulations were evaluated for each of the super disintegrants that were investigated. The created batches of tablets were subjected to a series of examinations, including weight variation, hardness, friability, wetting time, invitro dispersion time, drug content, and invitro dissolution. In order to determine the dose form of Rizatriptan Benzoate tablets, a UV spectrophotometric method that is uncomplicated, sensitive, rapid, accurate, cost-effective, and repeatable was developed. At a wavelength of 225 nm, rizatriptan benzoate exhibits the highest absorbance, and its molar absorption is measured at 1.619 Ao. The application of Beer's law was seen between 1 and 10 μg/ml. The findings of the analysis were validated by conducting statistical analysis and recovery studies. In order to validate the method, several different criteria were utilised, including linearity, accuracy, limit of detection (LOD), limit of quantification (LOQ), Sandell's sensitivity, and specificity. Through the use of the recommended method, it was discovered that the procedure of estimating the regular dosage of Rizatriptan Benzoate in both tablet and bulk forms is one that is accurate and precise. The optimised formulation took between fifteen and thirty seconds to spread throughout the body. In addition to this, it displayed a higher water absorption ratio and also released 99.60% of the medicine over a period of two minutes and fifteen seconds.