Assessment of Gonadotropins Level and Their Ratio In Gallstone Patients In Kolkata: A Cross-Sectional Study

Abstract

Gallstone disease (GSD) is  a  worldwide  disease ranging  from  10%  to  20%  of  the global population and  four times  higher  in  women  than  in  men. Several studies have proclaimed that risk of developing cholesterol gallstones is increased by pregnancy, contraceptive steroids and conjugated oestrogens suggesting that oestrogen could be an important risk factor in forming cholesterol gallstones by increasing the cholesterol saturation index, altering bile salt and promoting nucleation of cholesterol into crystals. To evaluate gonadotropin (FSH and LH) level and their ratio including their correlation with study variables among gallstones patients in Kolkata. 46 subjects were enrolled during a period of April to June, 2022 in West Bengal. Serum level of FSH and LH and its ratio were measured using sandwich ELISA. The data was analysed using statistical package of social science (SPSS) and results was expressed as percentage (%) and mean ± SD, and significance difference was considered as P<0.05. Analyses of frequency showed that GSD is more common in pre-menopause (76.1%) than post-menopause (23.9%). Independent t-test revealed that, FSH/LH ratio is significantly increased in gallstone patients in comparison with control group (P<0.048). In addition, Pearson’s correlation results noted positive correlation between both FSH and FSH/LH ratio with BMI while significant negative correlation in between LH and BMI. The data suggests that obese premenopausal women are much more susceptible to gallstones and FSH/LH ratio specifically is  for all intents and purposes higher  in  gallstone  patients, which specifically is fairly significant.