Relationship Between Hba1c AndSerum Iron And Transferrin Saturation In Iron-Deficiency Non-Diabetic Patients

Abstract

Objective: To determine if iron deficiency(ID) should be considered before making any treatment decisions based only on glycosylated hemoglobin (HbA1c) values, and to assess the effect of ID on theHbA1clevels of non-diabetic persons.

Methods: Between September 2023 and March 2024, a cross-sectional comparison study was carried out at the Index Medical College Hospital and Research Centre in Indore on non-diabetic patients based on fasting blood sugar of <100 mg/dl.There were two groups of patients. Patients with ID anemiawere included in group-1, while healthy people who were age and sex matched but did not have ID were included in group-2. A sample of blood was drawnfor serum iron, total iron binding capacity, CBC, and HbA1c. TSAT, or transferrin saturation, was computed. Student's t-test was used to compare quantitative variables between the group1 and group 2. Given that the data was not normally distributed, a correlation between HbA1c and iron and TSAT was performed in both groups using the Kendal tau-b test.

Results:Among the 198 patients, 83 (41.9%) men and 115 (59.1%) women. With a p-value <.001, the ID group's mean HbA1c level was considerably higher (5.88±0.43) than that of the non-ID group (5.51±0.48). Serum iron levels, transferrin saturation, and hemoglobin all showed a negative correlation with the HbA1c values. P-value less than.001.

Conclusion: Reduced serum Iron and TSAT was associated with increased HbA1c value. Prior to interpreting the HbA1c, an iron deficit must be treated.