Preparation, Investigation of Physical and Chemical Properties, and Assessment of Biological Activity of Novel Metal Complexes of Benzilmonoximehydrazide Derivatives

Abstract

N-[(2E)-2-{[(4-chlorophenyl)methylidene]hydrazinylidene}-1,2-diphenylethylidene] hydroxylamine (HBMHpCB) is introduced as a potential chelating agent for binding with Fe(II), Ni(II), Co(II), Zn(II) and Cu(II) metal ions. The synthesized HBMHpCB ligand and its resulting metal complexes are characterized using various spectroscopic and analytical techniques including UV-vis, IR, ¹H NMR, powder XRD, ESR, magnetic, and conductance measurement. Analysis of spectral data indicates that the ligand coordinates to the metal ions in a tridentate manner through the oxygen and nitrogen atoms of the oximino group and the azomethine moiety. Analytical findings suggest a stoichiometry of 1:2 (metal: ligand) for all Cu(II) and Ni(II) complexes. Additionally, the normal magnetic moments observed for Fe(II), Co(II), Ni(II), and Cu(II) complexes support a high spin octahedral structure, while the diamagnetic behavior of all Zn(II) complex is consistent with tetrahedral geometry. Conversely, the subnormal magnetic values observed for Cu(II) complexes suggest a binuclear structural arrangement. ESR spectra of the Cu(II) complexes further indicate a distorted octahedral geometry with significant intrageneric spin-exchange interaction. Furthermore, the synthesized compounds are screened for antibacterial, and antifungal activities.