A Study On The Correlation Between Clinical Features, Spirometry And Abg In Acute Exacerbation Of Obstructive Lung Disease

Abstract

Background: Limitation of exhaling capacity of air due to narrowing or damage of conducting tract or lungs is known as obstructive lung disease. Obstructive lung disease may consist of Bronchial asthma, cystic fibrosis, COPD and bronchiectasis marked by exacerbation and worsening of clinical presentation. Quantitization of impairment can be measured by bedside spiromentry measuring the FEV1 and FVC whereas exchange through alveoli may be measured by arterial blood gas analysis. The study depolys the tools readily available namely spirometry and ABG to correlate clinical features of 100 patients presenting with acute exacerbation of obstructive lung disease in a population setting of rural south india. The present study also aims to establish a predicting confidence of FEV1 value to ABG value changes and its use as a predictive marker for respiratory failure.

Methods: 100 patients presenting with acute exacerbation of obstructive lung disease in the department of general medicine VMKV MCH were subjected to Spirometry and ABG on admission and on the date of discharge.

Results:  PH <7.20 and spirometry showing pCO2 of more than 60 with paO2 less than 60 with FeV1 of less than 68% were found to be major factors associated with respiratory failure.

Conclusion: there is a significant correlation between FEV1 and pCO2 with clinical feature of acute exacerbation of obstructive lung disease. A Combination of spirometry with ABG increases the overall predicting acuracy of respiratory failure.