Brain-Derived Nerve Factor, A Novel Marker For Aggression Correlating Cognitive Ergonomics: A Retrospective Analysis Supporting Anthropometry Amongst The Pre-Pubertal Children Of West Bengal

Abstract

Brain derived nerve factor (BDNF) is considered to be one of the major neurotropic factors responsible for numerous psychological up regulations and down regulations. There are many potential researches evidenced about the role of BDNF in depression, anxiety and trauma. Serum BDNF, salivary BDNF even the samples of CSF (cerebro-spinal fluid) amongst the human from every parts of the globe indicated many biochemical chains of various signaling molecules like phosphatidylinositol 3 kinase, Phospholipase C and some of the families of mitogen activated protein kinase (MAP-Kinase) families which activate the genuine functions of BDNF. Aggression is a mixture of emotions like anger, antipathy and hyperkinetic behavior. Many biomolecules namely serum testosterone, cortisol appear to be the base line  molecules responsible of aggression along with emotions like stress, anxiety and hostility for both adult & children of pre and post puberty. Many anthropometric indices like fWHR (facial width to height ratio), 2D/4D ratio and Cranio-facial indices have showed direct relationship with testosterone and cortisol in promoting mood swings, hyperkinetic attitude and provocative actions amongst the children. Whereas the logic wheel for the BDNF in this regard is under research. It was also observed that the Leptin gene up-regulation changes the various craniofacial anthropometric dimensions lead to identification of novel cognitive markers for BDNF correlating aggression in the pre pubertal children of Bengal.