Formulation And Evaluation Of Floating Tablet Of Isradipine
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Abstract
Floating tablets of isradipine aim to improve drug bioavailability and therapeutic efficacy by prolonging gastric residence time and ensuring controlled release. Utilizing the natural polymer karaya gum, these tablets remain buoyant in the stomach, thereby extending the time for drug absorption and reducing degradation in the acidic environment. The tablets are prepared using a direct compression method, combining isradipine, HPMC, karaya gum, and sodium bicarbonate to generate gas, which helps the tablets float. Pre-compression evaluations showed good flow properties, while post-compression assessments confirmed consistent weight, hardness, and low friability. In vitro studies demonstrated sustained drug release over 12 hours, optimizing hypertension and angina treatment by maintaining stable drug levels and minimizing side effects. Stability tests indicated no significant changes in drug content and release profile over time, confirming the formulation's reliability.