Formulation And Characterization Of Combination Drug Microspheres For Diabetes Mellitus Management

Abstract

The current study aims to minimize dose frequency, dose amount and enhance patient compliance by designing and thoroughly analysing microspheres prepared with combined drugs that is metformin hydrochloride and saxagliptin, an antidiabetic medication which can enhance therapeutic effectiveness in combination therapy. The microsphere was developed using the solvent evaporation approach with metformin and saxagliptin as a main drug and polymers used are sodium alginate to enhance permeability along with guar gum and ethyl cellulose as the coating polymer. The microspheres were evaluated for percentage yield, particle size, drug entrapment efficiency and drug content, morphology, and in vitro drug release study. Fourier-transform infrared spectroscopy was used to examine the drug-polymer interaction; the results showed no incompatibility. The range of the drug entrapment efficiency was 60.63-95.51%. The produced microspheres of batch F6 had demonstrated, among other formulations, the ideal percent drug encapsulation of microspheres and the slow release of the drugs for roughly 14 hours. From this study, it is concluded that the developed polymeric microspheres of metformin hydrochloride and saxagliptin can be helpful for the management of diabetes mellitus by prolonged release of drugs, reduced dose frequency and dose interval and also by increasing patient compliance.