Formulation And Evaluation Of Bilayer Tablets For The Treatment Of Diabetes.

Abstract

This research was to formulate and evaluate bilayer tablets for the effective treatment of diabetes. Bilayer tablets, combining immediate and sustained-release layers, aim to provide a swift onset of action followed by prolonged therapeutic effects. The immediate-release layer was formulated using Metformin HCl, while the sustained-release layer contained Glipizide. Both layers were prepared using wet granulation and direct compression techniques. Reformulation studies, including drug-excipient compatibility and powder flow properties, were conducted to ensure stability and manufacturability. The bilayer tab is evaluated for its properties, like hardness, friability, weight variation, and thickness. Additionally, In vitro dissolution studies were performed to compare tab release profiles for the immediate and sustained-release layers. The immediate-release layer showed a rapid drug release within the first hour, ensuring quick therapeutic action. In contrast, the sustained-release layer exhibited a controlled release over 12 hours, maintaining steady plasma levels. Stability studies indicated that the bilayer tablets remained stable under accelerated conditions. The combination of Metformin HCl and Glipizide in a bilayer tablet offers an efficient therapeutic approach for managing diabetes by enhancing patient compliance through reduced dosing frequency and optimized drug release profiles.