Design and Assessment of Transfersomal Vesicles for Enhanced Transdermal Delivery of 5-Fluorouracil

Abstract

Transfersomes, ultra-deformable lipid vesicles, have emerged as promising carriers for transdermal drug delivery. These vesicles, comprising phospholipids and surfactants, facilitate the penetration of therapeutic agents through the skin barrier. This study focuses on formulating transfersomes loaded with 5-Fluorouracil (5-FU) and evaluating their physicochemical properties such as particle size, entrapment efficiency, zeta potential, and drug release behavior to enhance its dermal absorption.