Formulation And Evaluation Of Herbal Cream For The Treatment Of Wound Healing

Abstract

This study was to formulate and evaluate an herbal cream for wound healing using natural plant extracts known for their therapeutic properties. The selected herbs included Centella asiatica, which was chosen based on their well-documented efficacy in promoting skin repair and regeneration. Herbal extracts were prepared using ethanol and water as solvents, followed by standardization to ensure consistent active compound concentrations. The cream base was developed as an oil-in-water emulsion, optimized for pH, viscosity, and Spreadability to ensure suitability for topical application. Comprehensive stability studies were conducted to assess the formulation's physical, chemical, and microbial stability. The wound healing efficacy was evaluated through in vitro scratch assays and in vivo studies using a rat model, demonstrating significant improvements in wound contraction and re-epithelialization compared to controls. Additionally, dermal irritation tests confirmed the formulation’s safety for skin application. This research highlights the potential of combining traditional herbal medicine with modern formulation techniques to create effective and safe wound-healing products. The findings suggest that the developed herbal cream is a promising alternative to conventional treatments, offering natural and accessible solutions for wound care.