Thermal, Spectroscopic, Antibacterial And Antifungal Research On Β-Cyclodextrin-Inclusion Complexes Of 2-Cyclohexylimino-3-Phenyl-5-Arylidene-4-Thiazolidinone Derivatives.

Abstract

We have synthesized substituted 4-thiazolidinones using unsymmetrical thiourea, derived from cyclohexylamine and phenyl isothiocyanate as starting materials. The solubility of these compounds is reduced in polar solvents (water). Therefore, the incorporation of compounds is achieved by selecting an appropriate ratio between the component and β-cyclodextrin. The objective of this study is to produce molecules that are both more soluble and more bio accessible. The research has established the thermodynamic characteristics and spectral properties (UV, IR, and NMR) of the synthesized compounds and their constituents. The compounds' antibacterial and antifungal activities and incorporation can be assessed using bacteria like Escherichia coli and Bacillus subtilis and fungi like Candida albicans and Aspergillus niger.

. Analysis and thought have led to the conclusion that inclusion formation is more effective against bacteria than a single molecule.